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. 2015 Sep 25;10(9):e0139267. doi: 10.1371/journal.pone.0139267

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© 2015 Anderson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Unsupervised hierarchical clustering of kinomic peptide phosphorylation signal intensity (Y-axis) show three predominant cluster groups (labeled A, B and C on the dendrogram) among the 41 CC-RCC tumors. GeneGo MetaCore Process mapping of the significantly different peptides (p<0.002) among the clusters was performed and the dominant pathway for each cluster is indicated. Tumor number (RCC X) and clinical outcome is indicated on the X-axis (LocNoPro = locally controlled; LocPro = local progressor). Log fold changes as a deviation from the mean are displayed in the heatmap.