Table 2. Patient, age range and fold-ULN for HS, DS, KS, the cumulative levels of HS, DS and KS and DMB per diagnosis.

MPS subtype	Number of patients	Age range (yrs)	Median fold ULN (range)
			HS	DS	KS	HS, DS & KS	DMB
MPS I	18	0.8–32.6	12.1 (3.4–2.9)	101.8 (26.3–03.4)	0.6 (0.2–1.7)	10.8 (2.6–50.3)	4.4 (1.1–0.3)
MPS II	16	0.2–46.3	17.2 (10.0–23.6)	69.2 (35.3–139.4)	0.5 (0.4–1.6)	9.4 (5.3–23.6)	4.5 (1.7–8.5)
MPS III	34	3.3–66.9	28.3 (17.8–66.9)	1.3 (0.4–5.0)	0.5 (0.3–1.6)	12.0 (6.6–27.6)	3.1 (0.9–7.3)
MPS IVA	10	1.1–56.6	0.9 (0.4–1.4)	3.0 (1.0–4.6)	5.2 (2.4–14.6)	3.3 (1.6–8.2)	1.2 (0.6–2.4)
MPS IVB	3	21.5–51.3	1.2 (1.1–1.3)	1.3 (0.7–2.2)	6.8 (5.7–10.0)	3.9 (2.9–5.0)	0.7 (0.4–0.8)
MPS VI	17	0.1–57.8	0.6 (0.3–2.6)	31.3 (7.3–243.2)	0.6 (0.2–1.7)	3.0 (0.6–15.6)	1.9 (0.6–9.8)
MPS VII	2	21.0–21.3	1.0–5.4	1.5–2.6	0.1–0.9	0.7–3.5	0.5–0.7
ML II	2	0.2–0.3	0.8–2.8	1.6–5.3	1.0–1.7	0.9–2.1	0.8–1.4
MLIII	1	12.0	1.1	2.4	1.3	1.2	0.8