Diagram depicting potential research areas to understand some implementation challenges of novel human immunodeficiency virus (HIV) and tuberculosis (TB) diagnostics, such as the best use of point-of-care (POC) HIV viral load (VL), the distribution of diagnostic results directly to patients, the role of CD4 cell counts when VL is used for monitoring HIV antiretroviral (ARV) treatment, the education of patients about VL for monitoring HIV ARV treatment, the integration of HIV resistance under the new VL paradigm, and the improvement of specimen collection and transport strategies.