Fig. 8.

Global impact of KIEs on the isotopic content of pyruvate. The distributions of errors caused by KIEs on the (steady-state) abundances of pyruvate isotopomers (a) and isotopologues (b) were estimated from 10,000 sets of random enzyme levels. Error is defined as the absolute difference between isotopic data simulated with and without KIEs, i.e. with alpha coefficients set to their experimental values (Table 1) or to 1, respectively