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Experimental Treatments
| HiS MOR (n = 9) | LoS MOR (n = 11) | HiS SAL (n = 6) | LoS SAL (n = 6) | |
|---|---|---|---|---|
| Phase 2 (morphine dependence induction) treatments | MOR+SAL | MOR+SAL | SAL+SAL | SAL+SAL |
| Phase 4 (precipitated withdrawal) treatments | MOR+NAL | MOR+NAL | SAL+NAL | SAL+NAL |
HiS = high saccharin rats; LoS = low saccharin rats; MOR = morphine (10 mg/kg); NAL = naloxone (1 mg/kg); SAL = saline
