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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Exp Dermatol. 2015 Aug 18;24(10):773–778. doi: 10.1111/exd.12762

Fig 1. Delayed cutaneous wound healing after SIRT6 knockdown in db/db mice.

Fig 1

(A) Full-thickness skin wounds were created in diabetic db/db mice. (B) Representative photographs showing the macroscopic wound closure on day 14 postinjury from Control and SIRT6-KD diabetic wounds. (C) Microphotographs of wounds was analyzed at indicated time intervals to determine closure in control and SIRT6-KD. (D) Histopathology (H–E staining) of control and SIRT6-KD wound on day 14 postinjury. SIRT6-KD wounds showed less re-epithelialization and granulation formation. A stratified neoepidermis was visible on the edge of the wounds in control, whereas the epithelial tissue was disorganized in SIRT-KD wounds. Representative results from three independent experiments with three-four animals in each group are shown. All values represent the mean ± SEM. *p < 0.05 indicates significantly and **p < 0.01 indicates very significantly higher values observed in SIRT6-KD compared with control wound.