Table 3.
List of SNPs and probes of 34 genes identified through GWAS of asthma
| Gene | Chr | GWAS (reported, ref.*) | Population (reported) | SNP (reported) | SNP (tested) | Probe (tested) |
|---|---|---|---|---|---|---|
| ORMDL3 | 17 | 2 | European | rs7216389 | rs7216389 | A_23_P38190 |
| IL1RL1 | 2 | 5 | European | rs1420101 | rs1420101 | A_23_P51126 |
| WDR36 | 5 | 5 | European | rs2416257 | rs2416257 | A_23_P110598 |
| PDE4D | 5 | 25 | European American | rs1588265 | rs1588265 | A_23_P124456 |
| DENND1B | 1 | 26 | European American, African American | rs2786098 | rs2786098 | A_23_P201605 |
| RAD50 | 5 | 6 | European American | rs2244012 | rs2244012 | A_24_P226198 |
| IL13 | 5 | 6 | European American | rs20541 | rs20541 | A_23_P251031 |
| HLA-DQB1 | 6 | 6 | European American | rs1063355 | rs1063355 | A_23_P8108 |
| GSDMB | 17 | 3 | European | rs2305480 | rs2305480 | A_23_P66454 |
| IL33 | 9 | 3 | European | rs1342326 | rs992969 (r2=0.58, CEU) | A_23_P31945 |
| IL18R1 | 2 | 3 | European | rs3771166 | rs3771166 | A_23_P39735 |
| SMAD3 | 15 | 3 | European | rs744910 | rs744910 | A_23_P48936 |
| IL2RB | 22 | 3 | European | rs2284033 | rs2284033 | A_24_P203000 |
| RORA | 15 | 3 | European | rs11071559 | rs9920560 (r2=0.94, CEU) | A_23_P26124 |
| HLA-DPA1 | 6 | 27 | Japanese | rs987870 | rs987870 | A_23_P30913 |
| TSLP | 5 | 4 | European American, African American, Hispanic | rs1837253 | rs1837253 | A_23_P121987 |
| PYHIN1 | 2 | 4 | African American | rs1101999 | rs856090 (r2=0.64, YRI) | A_23_P365834 |
| NOTCH4 | 6 | 7 | Japanese | rs404860 | rs404860 | A_23_P365614 |
| AGER | 6 | 7 | Japanese | rs204993 | rs204993 | A_23_P93360 |
| C6orf10 | 6 | 7 | Japanese | rs3129943 | rs3129943 | A_23_P136734 |
| PBX2 | 6 | 7 | Japanese | rs204993 | rs204993 | A_23_P214658 |
| IKZF4 | 12 | 7 | Japanese | rs1701704 | rs1701704 | A_23_P358904 |
| CDK2 | 12 | 7 | Japanese | rs2069408 | rs2069408 | A_23_P98898 |
| USP38 | 4 | 7 | Japanese | rs7686660 | rs7686660 | A_23_P44734 |
| GAB1 | 4 | 7 | Japanese | rs3805236 | rs3805236 | A_23_P18505 |
| GATA3 | 10 | 7 | Japanese | rs10508372 | rs10508372 | A_23_P75056 |
| IL6R | 1 | 28 | European | rs4129267 | rs4129267 | A_24_P379413 |
| LRRC32 | 11 | 28 | European | rs7130588 | rs7130588 | A_24_P389916 |
| C11orf30 | 11 | 28 | European | rs7130588 | rs7130588 | A_23_P380834 |
| TNIP1 | 5 | 19 | European American | rs10036748 | rs10036748 | A_23_P19036 |
| CDHR3 | 7 | 29 | European | rs6967330 | rs17152490 (r2=0.58, CEU) | A_32_P204239 |
| ZBTB10 | 8 | 30 | European | rs7009110 | rs1543857 (r2=0.97, CEU) | A_24_P64071 |
| CLEC16A | 16 | 30 | European | rs62026376 | rs12919083 (r2=0.34, CEU) | A_32_P194246 |
| DEXI | 16 | 30 | European | rs62026376 | rs12919083 (r2=0.34, CEU) | A_24_P144377 |
*
The first GWAS studies reported the novel genes/SNPs were cited and GWAS studies were in chronological order.