Table 4.

eQTL of six most consistently replicated regions for asthma susceptibility

SNP	Gene	Chr	Location	Distance to Gene	Minor Allele	MAF	GSDMB				ORMDL3
							BEC		BAL		BEC		BAL
							Beta*	P-value (adjusted)	Beta*	P-value (adjusted)	Beta*	P-value	Beta*	P-value
rs8067378	GSDMB	17	3′	−9500	G	0.50	−0.52	1.3x10−4 (1.9x10−3)	−0.35	0.04	−0.05	0.74	0.11	0.52
rs2305480	GSDMB	17	coding	96_42	T	0.35	−0.45	4.4x10−4 (4.7x10−3)	−0.23	0.12	0.15	0.27	−0.05	0.75
rs7216389	GSDMB	17	intron	−1199	C	0.39	−0.43	1.1x10−3 (0.01)	−0.24	0.10	0.07	0.62	0.00	0.99
							TSLP				WDR36
rs1837253	TSLP	5	5′	−5518	T	0.26	−0.24	0.15	−0.03	0.86	−0.07	0.69	0.05	0.80
rs3806932	TSLP	5	5′	−1715	G	0.50	−0.39	2.3x10−3 (0.05)	−0.85	7.9x10−11 (1.0x10−4)	−0.07	0.61	−0.04	0.76
rs3806933	TSLP	5	5′	−648	T	0.36	−0.43	7.8x10−4 (0.02)	−0.82	1.5x10−9 (1.0x10−4)	−0.06	0.66	−0.01	0.94
rs2289276	TSLP	5	5UTR	117_81	T	0.24	−0.51	5.2x10−4 (0.01)	−0.66	2.7x10−5 (8.0x10−4)	−0.21	0.15	−0.09	0.57
rs2416257	WDR36	5	intron	−798	A	0.12	−0.17	0.44	−0.81	5.5x10−4 (0.02)	0.29	0.20	0.20	0.41
							IL13				RAD50
rs2244012	RAD50	5	intron	−6166	C	0.38	−0.21	0.11	0.19	0.18	0.10	0.47	0.05	0.71
rs20541	IL13	5	coding	97_10	T	0.25	0.05	0.76	0.32	0.07	0.17	0.27	0.12	0.48
							IL1RL1				IL18R1
rs1420101	IL1RL1	2	coding	68_101	A	0.38	−0.16	0.30	−0.22	0.21	0.02	0.88	−0.10	0.57
rs12999517	IL1RL1	2	intron	−236	C	0.14	−0.02	0.90	−0.68	4.4x10−4 (9.5x10−3)	0.33	0.08	−0.12	0.56
rs3771166	IL18R1	2	intron	−1694	T	0.41	0.15	0.27	−0.14	0.31	−0.16	0.23	−0.06	0.68
							IL33
rs992969	IL33	9	5′	−31981	A	0.27	0.69	1.3x10−6 (1.0x10−4)	0.11	0.53
rs3939286	IL33	9	5′	−31579	A	0.33	0.50	2.0x10−4 (5.9x10−3)	0.21	0.18
							HLA-DQB1
rs1063355	HLA-DQB1	6	3UTR	50_298	A	0.46	0.63	8.0x10−7 (1.0x10−4)	0.05	0.71

^*Beta is the correlation coefficient of SNP vs. gene expression value on the basis of minor allele from linear additive model.