Table 5.
eQTL of 7 of 24 other asthma genes (with significant eQTL)
| SNP | Gene | Location | Distance to Gene | Chr | Position | Major Allele | Minor Allele | MAF | TNIP1 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| BEC | BAL | |||||||||||
|
| ||||||||||||
| Beta* | P-value (adjusted) | Beta* | P-value (adjusted) | |||||||||
| rs10036748 | TNIP1 | intron | −2295 | 5 | 150458146 | C | T | 0.43 | 0.02 | 0.87 | 0.04 | 0.74 |
| rs871269 | TNIP1 | intron | −568 | 5 | 150432388 | C | T | 0.38 | 0.10 | 0.49 | −0.47 | 1.5x10−3 (0.03) |
|
| ||||||||||||
| NOTCH4 | ||||||||||||
|
| ||||||||||||
| rs404860 | NOTCH4 | intron | −377 | 6 | 32184345 | T | C | 0.2103 | 0.21 | 0.22 | 0.11 | 0.5518 |
| rs2071279 | NOTCH4 | intron | −25 | 6 | 32164874 | G | T | 0.28 | −0.13 | 0.37 | −0.54 | 3.3x10−4 (0.05) |
|
| ||||||||||||
| C11orf30 | ||||||||||||
|
| ||||||||||||
| rs4300410 | C11orf30 | intron | −150 | 11 | 76163151 | C | T | 0.43 | −0.08 | 0.52 | −0.48 | 2.6x10−4 (0.01) |
| rs10793169 | C11orf30 | intron | −346 | 11 | 76164012 | G | A | 0.43 | −0.08 | 0.52 | −0.48 | 2.6x10−4 (0.01) |
| rs4245443 | C11orf30 | intron | −40 | 11 | 76183924 | G | A | 0.42 | −0.09 | 0.51 | −0.46 | 6.1x10−4 (0.02) |
| rs2508740 | C11orf30 | intron | −4 | 11 | 76227182 | A | G | 0.39 | −0.04 | 0.75 | −0.45 | 8.4x10−4 (0.03) |
| rs2513513 | C11orf30 | 3UTR | 342_1056 | 11 | 76261533 | G | A | 0.42 | −0.08 | 0.52 | −0.44 | 1.0x10−3 (0.04) |
| rs2513525 | C11orf30 | 3′ | −4119 | 11 | 76266708 | C | A | 0.42 | −0.06 | 0.62 | −0.43 | 9.1x10−4 (0.03) |
| rs7130588 | C11orf30 | 3′ | −8094 | 11 | 76270683 | A | G | 0.32 | −0.23 | 0.11 | −0.26 | 0.09 |
|
| ||||||||||||
| SMAD3 | ||||||||||||
|
| ||||||||||||
| rs4776890 | SMAD3 | intron | −34347 | 15 | 67393045 | T | G | 0.36 | 0.48 | 1.0x10−4 (5.3x10−3) | −0.06 | 0.68 |
| rs744910 | SMAD3 | intron | −10448 | 15 | 67446785 | G | A | 0.40 | 0.09 | 0.57 | 0.11 | 0.48 |
|
| ||||||||||||
| CDHR3 | ||||||||||||
|
| ||||||||||||
| rs17152490 | CDHR3 | 3′ | −3361 | 7 | 105677579 | G | A | 0.14 | 0.52 | 0.01 | −0.08 | 0.69 |
|
| ||||||||||||
| ZBTB10 | ||||||||||||
|
| ||||||||||||
| rs1543857 | ZBTB10 | 5′ | −103224 | 8 | 81295224 | A | G | 0.48 | −0.32 | 0.02 | −0.12 | 0.41 |
|
| ||||||||||||
| DEXI | ||||||||||||
|
| ||||||||||||
| rs12919083 | CLEC16A | intron | −25542 | 16 | 11188930 | A | C | 0.37 | 0.18 | 0.28 | 0.63 | 1.0x10−4 (3.9x10−3) |
Beta is the correlation coefficient of SNP vs. gene expression value on the basis of minor allele from linear additive model.