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. Author manuscript; available in PMC: 2016 Sep 25.
Published in final edited form as: Circ Res. 2015 Jul 30;117(8):695–706. doi: 10.1161/CIRCRESAHA.115.306838

Figure 3. CardioChimeras improve left ventricular wall structure and cardiac function after myocardial injury.

Figure 3

(A) Longitudinal assessment of anterior wall thickness during systole (mm) over 18 weeks. (B) Heart weight to body weight ratio (mg/g) at 12 WPI (C) 18 WPI. Sample sizes of 3–5 mice per group. (D) Longitudinal assessment of ejection fraction (%). (E) Positive and (F) Negative developed pressure over time represented as mmHg/sec at 4, 12 and 18 WPI. (G) Change in infarct size between 4 and 12 weeks time points. P values were determined by one-way ANOVA compared to PBS treated controls. (H–N) Masson’s Trichrome staining and representative images of infarct size and fibrosis in (H) Sham, (I) PBS, (J) MSC, (K) CPC, (L) CPC + MSC, (M) CC1 and (N) CC2. Sample sizes are specified in the Online Table II. All statistical values were determined by two-way ANOVA compared to PBS treated hearts. * p<0.05, ** p<0.01, *** p<0.001. Colors of asterisk(s) correspond to heart group. Scale bar is 250µm.