Figure 5.

Proposed model of the interactions leading to CXCL10 production by T cells and antigen‐presenting cells (APCs). The T cell is activated by its cognate antigen presented on an APC. The T cell secretes interferon‐γ (IFNγ) in response to the antigen and senses autocrine or paracrine IFNγ via the IFNγ receptor (IFNγR). The T cell and APC secrete CXCL10 in this antigen‐specific interaction, which recruits additional CXCR3⁺ cells into the area. The signal that tells the APC to produce CXCL10 was not investigated in the current experiments, but may be related to expression of the IFNγR by APCs or other signals.