Table 2.
Association between EMT markers and clinicopathologic factors of lung adenocarcinoma patients
| Factors preserve | E-cadherin No. (%) | vimentin No. (%) | fibronectin No. (%) | SMA No. (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| preserve | loss | p-value | low | high | p-value | low | high | p-value | low | high | p-value | ||
| Age (years) | ≤ 65 | 41 (57.7) | 15 (57.7) | .996 | 34 (55.7) | 22 (61.1) | .605 | 41 (60.3) | 15 (51.7) | .434 | 51 (62.2) | 5 (33.3) | .037 |
| > 65 | 30 (42.3) | 11 (42.3) | 27 (44.3) | 14 (38.9) | 27 (39.7) | 14 (48.3) | 31 (37.8) | 10 (66.7) | |||||
| Sex | Female | 39 (54.9) | 16 (61.5) | .561 | 38 (62.3) | 17 (47.2) | .148 | 37 (54.4) | 18 (62.1) | .486 | 48 (58.5) | 7 (46.7) | .394 |
| Male | 32 (45.1) | 10 (38.5) | 23 (37.7) | 19 (52.8) | 31 (45.6) | 11 (37.9) | 34 (41.5) | 8 (53.3) | |||||
| Smoking | ≤ 10 PY | 41 (60.3) | 18 (69.2) | .423 | 39 (66.1) | 20 (57.1) | .385 | 38 (57.6) | 21 (75) | .110 | 49 (62) | 10 (66.7) | .733 |
| > 10 PY | 27 (39.7) | 8 (30.8) | 20 (33.9) | 15 (42.9) | 28 (42.4) | 7 (25) | 30 (38) | 5 (33.3) | |||||
| pT | 1 | 31 (43.7) | 11 (42.3) | .857 | 35 (57.4) | 7 (19.4) | .001 | 31 (45.6) | 11 (37.9) | .771 | 33 (40.2) | 9 (60) | .361 |
| 2 | 31 (43.7) | 10 (38.5) | 17 (27.9) | 24 (66.7) | 27 (39.7) | 14 (48.3) | 36 (43.9) | 5 (33.3) | |||||
| 3 | 6 (8.5) | 3 (11.5) | 5 (8.2) | 4 (11.1) | 7 (10.3) | 2 (6.9) | 9 (11) | 0 (0) | |||||
| 4 | 3 (4.2) | 2 (7.7) | 4 (6.6) | 1 (2.8) | 7 (10.3) | 2 (6.9) | 4 (4.9) | 1 (6.7) | |||||
| pN | 0 | 41 (64.1) | 20 (80) | .240 | 40 (71.4) | 21 (63.6) | .227 | 45 (71.4) | 16 (61.5) | .349 | 53 (70.7) | 8 (57.1) | .538 |
| 1 | 8 (12.5) | 0 (0) | 3 (5.4) | 5 (15.2) | 6 (9.5) | 2 (7.7) | 7 (9.3) | 1 (7.1) | |||||
| 2 | 14 (21.9) | 5 (20) | 13 (23.2) | 6 (18.2) | 12 (19) | 7 (26.9) | 14 (18.7) | 5 (35.7) | |||||
| 3 | 1 (1.6) | 0 (0) | 0 (0) | 1 (3) | 0 (0) | 1 (3.8) | 1 (1.3) | 0 (0) | |||||
| pM | 0 | 62 (87.3) | 26 (100) | .057 | 56 (91.8) | 32 (88.9) | .633 | 62 (91.2) | 26 (89.7) | .813 | 73 (89) | 15 (100) | .178 |
| 1 | 9 (12.7) | 0 (0) | 5 (8.2) | 4 (11.1) | 6 (8.8) | 3 (10.3) | 9 (11) | 0 (0) | |||||
| Stage | 1 | 37 (52.1) | 17 (65.4) | .127 | 37 (60.7) | 17 (47.2) | .336 | 40 (58.8) | 14 (48.3) | .696 | 46 (56.1) | 8 (53.3) | .131 |
| 2 | 12 (16.9) | 2 (7.7) | 6 (9.8) | 8 (22.2) | 10 (14.7) | 4 (13.8) | 13 (15.9) | 1 (6.7) | |||||
| 3 | 13 (18.3) | 7 (26.9) | 13 (21.3) | 7 (19.4) | 12 (17.6) | 8 (27.6) | 14 (17.1) | 6 (40) | |||||
| 4 | 9 (12.7) | 0 (0) | 5 (8.2) | 4 (11.1) | 6 (8.8) | 3 (10.3) | 9 (11) | 0 (0) | |||||
| Lymphovascular invasion | No | 30 (42.3) | 9 (34.6) | .497 | 27 (44.3) | 12 (33.3) | .289 | 30 (44.1) | 9 (31) | .229 | 32 (39) | 7 (46.7) | .579 |
| Yes | 41 (57.7) | 17 (65.4) | 34 (55.7) | 24 (66.7) | 38 (55.9) | 20 (69) | 50 (61) | 8 (53.3) | |||||
| Pleural invasion | |||||||||||||
| No | 45 (63.4) | 12 (46.2) | .127 | 41 (67.2) | 16 (44.4) | .028 | 39 (57.4) | 18 (62.1) | .666 | 46 (56.1) | 11 (73.3) | .212 | |
| Yes | 26 (36.6) | 14 (53.8) | 20 (32.8) | 20 (55.6) | 29 (42.6) | 11 (37.9) | 36 (43.9) | 4 (26.7) | |||||
PY, pack years.