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Aliskiren inhibits cell proliferation. The 786-O and ACHN cells are incubated with various concentrations of aliskiren (0-100 μM) for 24 h and 48 h respectively, and the cell viability is examined by CCK8 assay (A). The mRNA (B) and protein (C) expression of notch1 and KRT6 are measured by RT-PCR and western blotting respectively, and protein bands are quantified (D). Values are expressed as mean ± SEM, n = 3 in each group. *P < 0.05, **P < 0.01 versus control group.
