Table 2.
Univariate and multivariate analysis of prognostic factors in LSCC for overall survival
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| PXN expression | 2.748 | 1.224-4.061 | 0.006* | 2.572 | 1.056-3.861 | 0.002* |
| Gender (Male vs. Female) | 1.969 | 1.024-2.316 | 0.582 | |||
| Age (< 55 vs. ≥ 55) | 1.546 | 0.986-2.176 | 0.065 | |||
| Alcohol consumption (Yes vs. No) | 1.228 | 0.593-2.038 | 0.486 | |||
| Smoking consumption (Yes vs. No) | 0.964 | 0.495-1.698 | 0.078 | |||
| Tumor Location (Superaglottic vs. Glottic vs. Subglottic) | 1.508 | 1.045-3.254 | 0.118 | |||
| Tumor size (< 2.5 vs. ≥ 2.5) | 0.896 | 0.526-1.640 | 0.086 | |||
| Histological differentiation (Well/moderate vs. Poor) | 1.956 | 1.023-3.243 | 0.046* | 1.450 | 0.516-2.356 | 0.479 |
| Lymph node metastasis (Negative vs. Positive) | 1.893 | 1.289-3.905 | 0.018* | 1.345 | 0.912-4.129 | 0.013* |
| Invasive depth (T1/T2 vs. T3/T4) | 1.378 | 0.855-1.897 | 0.022* | 1.495 | 0.925-2.120 | 0.207 |
| TNM stage (I-II vs. III-IV) | 1.192 | 0.846-1.806 | 0.023* | 1.163 | 0.875-2.062 | 0.006* |
HR, hazard ratio; CI, confidence interval;
*
P-value < 0.05 was considered statistically significant.