Table 1.

Pharmacokinetic parameters of bupropion and phenacetin in control-group and MS-275-group rats (mean ± SD, n = 10)

Parameters		AUC(0-t)	AUC(0-∞)	t1/2	CL	V	Cmax
		ng/mL h*	ng/mL h*	h	L/h/kg	L/kg	ng/mL
Bupropion (CYP2B6)	Low	286.1 ± 132.7	382.8 ± 155.5	1.7 ± 0.9	31.9 ± 18.0	80.8 ± 64.9	116.0 ± 72.6
	Medium	195.4 ± 63.3	210.6 ± 68.7	1.4 ± 0.4**	54.6 ± 26.7	107.5 ± 55.6*	91.6 ± 35.9*
	High	114.8 ± 15.2**	117.2 ± 15.4**	1.0 ± 0.2	86.6 ± 11.8**	125.2 ± 25.4**	73.1 ± 24.1*
	Control	235.6 ± 67.0	238.6 ± 67.4	0.9 ± 0.2	45.2 ± 13.7	55.9 ± 23.7	149.6 ± 58.3
Phenacetin (CYP1A2)	Low	5990.4 ± 1810.1	5994.1 ± 1806.7	0.7 ± 0.5	1.8 ± 0.5	2.0 ± 1.2*	4258.2 ± 1159.4*
	Medium	4408.5 ± 1841.9*	4432.7 ± 1849.0*	0.6 ± 0.3	2.5 ± 0.6**	1.9 ± 0.8**	3187.3 ± 494.0**
	High	3949.3 ± 1438.7**	3991.7 ± 1395.5**	1.0 ±0.8*	2.8 ±1.0**	4.7 ± 2.9*	2075.2 ± 466.8**
	Control	6785.2 ± 1393.3	6787.2 ± 1393.3	0.4 ± 0.1	1.6 ± 0.5	0.8 ± 0.3	5829.5 ± 1179.7

Compared MS-275 group with the control group,

^*P<0.05;

^**P<0.01.