Table 2.

Pharmacokinetic parameters of tolbutamide and midazolam in control-group and MS-275-group rats (mean ± SD, n = 10)

Parameters		AUC(0-t)	AUC(0-∞)	t1/2	CL	V	Cmax
		ng/mL h*	ng/mL h*	h	L/h/kg	L/kg	ng/mL
Tolbutamide (CYP2C9)	Low	63433.0 ± 15143.5**	64600.5 ± 14541.2**	4.9 ± 1.2	0.016 ± 0.003**	0.11 ± 0.03*	5723.3 ± 1189.5**
	Medium	62062.1 ± 14665.0**	64652.5 ± 13687.3**	6.7 ± 1.8	0.016 ± 0.003**	0.15 ± 0.04**	4423.4 ± 1072.2**
	High	50095.6 ± 8644.5**	52164.7 ± 9182.5**	6.7 ± 2.9	0.020 ± 0.003**	0.18 ± 0.06**	3821.0 ± 313.2**
	Control	99947.8 ± 27778.3	100707.5 ± 29200.8	5.7 ± 2.0	0.011 ± 0.003	0.08 ± 0.02	7666.9 ± 768.9
Midazolam (CYP3A4)	Low	242.1 ± 161.5	275.3 ± 209.2	1.7 ± 0.8*	62.6 ± 52.3	163.2 ± 182.6	132.2 ± 83.2
	Medium	88.4 ± 23.1*	89.9 ± 23.7*	0.8 ± 0.4	118.6 ± 34.0**	135.4 ± 53.0**	69.5 ± 22.9*
	High	87.5 ± 45.6*	92.0 ± 45.3*	1.0 ± 0.5	134.6 ± 67.0**	193.8 ± 132.2**	59.0 ± 43.1**
	Control	319.0 ± 207.8	320.9 ± 208.4	0.7 ± 0.2*	40.8 ± 20.0	43.1 ± 26.2	257.6 ± 166.8

Compared MS-275 group with the control group,

^*P<0.05;

^**P<0.01.