Table 3.
Pharmacokinetic parameters of metroprolol and and omeprazole in control-group and MS-275-group rats (mean ± SD, n = 10)
| Parameters | AUC(0-t) | AUC(0-∞) | t1/2 | CL | V | Cmax | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| ng/mL h* | ng/mL h* | h | L/h/kg | L/kg | ng/mL | ||
| Metroprolol (CYP2D6) | Low | 1459.0 ± 398.5 | 1493.7 ± 397.8 | 1.9 ± 0.7 | 7.2 ± 2.2 | 20.0 ± 9.1 | 403.9 ± 121.7 |
| Medium | 1016.4 ± 223.9 | 1025.2 ± 222.9 | 1.8 ± 0.9 | 10.2 ± 2.1 | 27.3 ± 19.0 | 374.1 ± 63.7** | |
| High | 746.4 ± 277.1** | 751.2 ± 275.9** | 1.3 ± 0.2 | 14.4 ± 3.4** | 27.9 ± 8.7 | 309.9 ± 71.6** | |
| Control | 1151.8 ± 201.8 | 1158.3 ± 196.6 | 1.3 ± 0.3 | 8.8 ± 1.4 | 16.4 ± 6.4 | 563.1 ± 156.6 | |
| Omeprazole (CYP2C19) | Low | 361.2 ± 172.8** | 370.7 ± 172.0** | 1.8 ± 0.5 | 32.3 ± 13.7** | 93.3 ± 62.6** | 324.2 ± 190.3** |
| Medium | 327.8 ± 95.8** | 341.8 ± 87.0** | 1.9 ± 1.0 | 30.9 ± 7.4** | 88.6 ± 66.1 | 294.6 ± 129.9** | |
| High | 367.7 ± 158.8** | 455.1 ± 112.5** | 10.1 ± 17.8 | 28.5 ± 20.0 | 160.4 ± 122.7** | 179.9 ± 68.8** | |
| Control | 905.9 ± 279.7 | 923.0 ± 295.3 | 1.4 ± 0.9 | 12.2 ± 4.9 | 23.2 ± 11.7 | 795.3 ± 229.5 | |
Compared MS-275 group with the control group,
*
P<0.05;
**
P<0.01.