Table 2. Diagnostic performances of Protein Fingerprint markers for the detection of significant (≥F2) and advanced (≥F3) fibrosis.

Fibrosis stage	Marker	Sensitivity (%)	Specificity (%)	AUC [95%CI]	P-Value
≥F2 (Prevalence for ≥F2: 53%)	C3M	19.9	93.0	0.56 [0.51–0.61]	0.031
	C4M	48.4	64.0	0.56 [0.51–0.61]	0.031
	C6M	51.9	58.9	0.55 [0.50–0.60]	0.068
	Pro-C3	68.4	72.9	0.75 [0.71–0.79]*	<0.0001
	P4NP7S	55.6	53.7	0.54 [0.49–0.59]	0.210
≥F3 (Prevalence for ≥F3: 20%)	C3M	45.0	77.3	0.64 [0.59–0.68]	0.0003
	C4M	42.5	80.4	0.64 [0.60–0.69]	0.0001
	C6M	66.2	57.3	0.64 [0.59–0.69]	0.0001
	Pro-C3	83.7	75.4	0.86 [0.82–0.89]*	<0.0001
	P4NP7S	68.7	59.8	0.63 [0.58–0.68]	0.003

*) AUC significantly different from C3M, C4M, C6M and P4NP7S for detecting ≥F2 and ≥F3