Table 3. Diagnostic performance of combination models for the detection of significant (≥F2) and advanced (≥F3) fibrosis.

Fibrosis stage	Marker	Sensitivity (%)	Specificity (%)	AUC [95%CI]	P-Value
≥F2 (Prevalence for ≥F2: 53%)	FIB-4	69.6	72.1	0.76 [0.72–0.80]	<0.0001
	APRI	56.8	82.2	0.74 [0.69–0.78]	<0.0001
	Model 1	63.5	78.4	0.76 [0.72–0.81]	<0.0001
	Model 2	69.8	78.7	0.80 [0.76–0.84]*	<0.0001
≥F3 (Prevalence for ≥F3: 20%)	FIB-4	76.2	76.6	0.84 [0.80–0.86]	<0.0001
	APRI	76.2	75.7	0.82 [0.78–0.86]	<0.0001
	Model 1	89.0	76.0	0.88 [0.84–0.91]†	<0.0001
	Model 2	87.0	76.5	0.88 [0.84–0.91]	<0.0001

*) AUC significantly different from Pro-C3 and APRI for detecting ≥F2

†) AUC significantly different from APRI for detecting ≥F3