Table 4.

Alcohol consumption at HUNT1 and the association with Alzheimer’s disease up till 27 years later

	Hazard ratios (95 % Confidence Intervals, CI) alcohol consumption last 14 days
	Abstainers	Drinking 0 times, not abstainers	Drinking 5 or more times	Unknown
Alzheimer’s disease, crude	2.21 (1.68–2.91) p < 0.001	1.86 (1.50–2.31) p < 0.001	1.61 (1.10–2.36) p = 0.015	4.02 (2.83–5.71) p < 0.001
Alzheimer’s disease, adjusted for ageb, sex	1.26 (0.94–1.69) p = 0.127	1.34 (1.07–1.68) p = 0.010	1.52 (1.03–2.22) p = 0.033	1.99 (1.38–2.88) p < 0.001
Alzheimer’s disease, fully adjusted modela	1.09 (0.80–1.48) p = 0.595	1.20 (0.96–1.51) p = 0.114	1.47 (1.00–2.16) p = 0.048	1.73 (1.17–2.55) p = 0.006

Cox survival regression analysis. HUNT1Q2-participants born between 1905 and 1946 (n = 595/N = 40,435)

Dementia group included Alzheimer cases only. Other dementia cases in these analyses were censored. Reference group: Respondents reporting to drink alcohol 1–4 times the last fortnight

^a adjusted for age, ^b (ageHUNT1-45)², sex, age, education, severe hypertension (≥ 160/90), BMI ≥ 30, smoking and symptoms of depression