Table 2.

Adjusted linear mixed models estimating the individual associations between each independent variable and CRF over time

	B	95 %CI	p value
Time
T1	Ref	Ref
T2	0.10	−0.15–0.35	0.44
T3	0.12	−0.13–0.38	0.34
Sociodemographic characteristics
Sex			<0.001
Male	−1.24	−1.86 to −0.62
Female	Ref	Ref
Age (years)			0.02
≤ 65	0.62	0.12–1.14
> 65	Ref	Ref
Partner			0.01
Yes	−0.82	−1.46 to −0.17
No	Ref	Ref
Educational level
Low	1.03	0.23–1.84	0.01
Middle	1.13	0.55–1.72	<0.001
High	Ref	Ref
Clinical characteristics
Years since diagnosis			0.20
≤ 5	0.30	−0.16–0.75
> 5	Ref	Ref
Stage
I	−1.20	−3.01–0.61	0.20
II	−0.83	−2.64–0.98	0.37
III	−1.25	−3.07–0.57	0.18
IV	Ref	Ref
Chemotherapy
Yes	Ref	Ref
No	−0.86	−1.72 to −0.01	0.05
Radiotherapy
Yes	Ref	Ref
No	−0.44	−1.09–0.20	0.18
Number of comorbid conditions
None	−1.63	−2.07 to −1.19	<0.001
One	−0.80	−1.15 to −0.44	<0.001
Two or more	Ref	Ref
BMI	0.12	0.07–0,17	<0.001
Behavior/well-being
Pain
Between	0.15	0.14–0.17	<0.001
Within	0.03	0.03–0.04	<0.001
Insomnia
Between	0.10	0.09–0.11	<0.001
Within	0.02	0.01–0.03	<0.001
Social functioning
Between	−0.21	−0.23 to −0.20	<0.001
Within	−0.04	−0.05 to −0.03	<0.001
Emotional functioning
Between	−0.23	−0.24 to −0.21	<0.001
Within	−0.07	−0.08 to −0.06	<0.001
Cognitive functioning
Between	−0.22	−0.23 to −0.21	<0.001
Within	−0.06	−0.07–0.05	<0.001
Global quality of life
Between	−0.27	−0.28 to −0.25	<0.001
Within	−0.07	−0.08 to −0.06	<0.001
Anxiety
Between	1.04	0.97–1.12	<0.001
Within	0.50	0.43–0.57	<0.001
Depressive symptoms
Between	1.31	1.24–1.38	<0.001
Within	0.60	0.54–0.67	<0.001
Functional status
Physical functioning
Between	−0.21	−0.23 to −0.20	<0.001
Within	−0.08	−0.09 to −0.06	<0.001
Role functioning
Between	−0.17	−0.18 to −0.16	<0.001
Within	−0.05	−0.05 to −0.04	<0.001
Occupation
Yes	Ref	Ref
No	0.64	−0.21–1.51	0.14
Moderate to vigorous physical activity level
Between	−0.14	−0.18 to −0.10	<0.001
Within	−0.03	−0.05 to −0.01	<0.01