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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Neurooncol. 2015 Jun 25;124(3):365–372. doi: 10.1007/s11060-015-1853-7

Figure 1.

Figure 1

Mechanism of action of VB-111. (1) Viral vector internalized into endothelial cells in angiogenic blood vessels. (2) PPE-1-3x promoter causes Fas-TNFR-1 to be expressed on the endothelial cell surface. (3) Cell apoptosis is activated when circulating TNF-α interacts with Fas-TNFR-1 receptor.