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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Eur J Pharmacol. 2015 May 14;763(0 0):196–205. doi: 10.1016/j.ejphar.2015.05.013

Fig. 1.

Fig. 1

Structures of representative class A GPCRs and positions of orthosteric ligand binding pockets. (A) Structure of the β2-adrenergic receptor with a bound inverse agonist carazolol (PDB: 2RH1). (B) The β2-adrenergic receptor with bound carazolol viewed from the extracellular side. (C) Structure of the sphingosine-1-phosphate receptor with a bound antagonist lipid-mimic ML056 (PDB: 3V2Y). (D) Structure of the NTSR1 neurotensin receptor with a bound agonist peptide neurotensin8–13 (PDB: 4GRV). In all panels the receptor is color coded from N- to C-termini and the ligand is shown in stick representation and space-filling spheres. Extracellular (ECL) and intracellular (ICL) loops and the seven transmembrane helices are labeled. Disulfide bonds, palmitoylation at the C-terminus, and glycans at the N-terminus are also shown in stick representation. All figures were prepared with PyMol (Schrodinger).