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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Eur J Pharmacol. 2015 May 14;763(0 0):196–205. doi: 10.1016/j.ejphar.2015.05.013

Fig. 4.

Fig. 4

Structural determinants for ECD-mediated class B GPCR subtype selectivity. (A) Superposition of the CRF1 receptor and CRF2α receptor ECDs with bound CRF (PDB: 3EHU) and Ucn3 (PDB: 3N93) peptide fragments, respectively. Receptor and peptide residues involved in selectivity are labeled. (B, C) Electrostatic surface potentials [from −5 (red) to +5 (blue) kT/e] of the CRF1 receptor ECD highlighting the negative area near CRF1 receptor E104 (B) and of the CRF2α receptor ECD highlighting the neutral area near CRF2α receptor P100 (C).