Figure 6. Purkinje neurons toggle between bursting and tonic states as a function of membrane potential and AMPAR-mediated synaptic input.
(A) Representative trace of a bursting cell (bursts not shown) which rested at −65 mV spontaneously depolarizing and spiking tonically. (B) Scatter plot of membrane potential of cells in tonic vs bursting modes showing that tonic modes occur at more depolarized potentials than bursting mode (N = 8 cells for tonic mode and 11 cells for bursting mode). (C) Representative trace of a cell in the absence (top trace) and presence (bottom trace) of APV. This cell rested at −58 mV (N = 6 cells). (D) Representative trace of a cell in the absence (top trace) and presence (bottom trace) of Gabazine. This cell rested at −57 mV (N = 10 cells). (E) Representative trace of a cell in the absence (top trace) and presence (bottom trace) of CNQX. This cell rested at −60 mV (N = 12 cells).