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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Sci Transl Med. 2015 Aug 26;7(302):302ra135. doi: 10.1126/scitranslmed.aab1216

Fig. 3. Naïve B cell repertoire richness is decreased in CVID.

Fig. 3

(A) The estimated lower bound of the unmutated IgH repertoire richness plotted against sequence read numbers per sample, both in log-scale. A linear regression model is shown for CVID Group I and II and healthy controls with the 95% confidence band. Both CVID groups show decreased richness compared to healthy controls. (B) Mutated IgH sequences show comparable richness in CVID and healthy controls. Repertoire richness estimates were calculated with the Chao2 estimator (see Methods).