Table 3.
Comparison of neuropathology kinetics.
| Day 3 pi | Day 7 pi | Day 12 pi | Day 18 pi | |
|---|---|---|---|---|
| WNVNSW2011 (weanling NZWRs) | Mn and rare htl near CVO and neuropil of brain (peak score = 1, n = 2/3) | Mn in meninges, neuropil of brain, olfactory bulbs, spinal cord, perineurium and/or nerve fibres of spinal nerves in cauda equine (peak score = 2, n = 4/9) | Mn in meninges, neuropil of brain and cranial cervical spinal cord (peak score = 1, n = 4/6) | Mn in meninges, neuropil of brain near CVO and cranial cervical spinal cord (peak score = 1, n = 2/6) |
| MVE1-51 (weanling NZWRs) | No pathology (n = 0/3) | Mn with occasional htl in meninges, neuropil of brain (extensive with neuronophagia), olfactory bulbs, spinal cord, perineurium of spinal nerves and/or dorsal root ganglion in cauda equine (peak score = 3, n = 6/6) | Mn,with occasional htl in meninges, neuropil of brain (extensive) with neuronophagia+ (peak score = 3, n = 4/6) | Mn,with occasional htl in meninges, neuropil of brain (extensive)+ (peak score = 2, n = 2/6) |
| WNVNSW2011 (CTRs) | No pathology (n = 0/3) | Mn in meninges, neuropil of brain and spinal cord (peak score = 2, n = 1/3) | N/D | N/D |
| WNVTX8667 (CTRs) | No pathology (n = 0/3) | Mn in meninges and neuropil of brain (extensive; peak score = 3, n 2/3) | N/D | N/D |
Mn, mononuclear leukocytes; Htl, heterophils; CVO, circumventricular organ; peak score, peak neuropathology score in the CNS (out of 5). + Spinal cord and olfactory bulbs were not examined, N/D: not done.