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. 2015 Jul 14;4(3):529–558. doi: 10.3390/pathogens4030529

Table 3.

Comparison of neuropathology kinetics.

Day 3 pi Day 7 pi Day 12 pi Day 18 pi
WNVNSW2011 (weanling NZWRs) Mn and rare htl near CVO and neuropil of brain (peak score = 1, n = 2/3) Mn in meninges, neuropil of brain, olfactory bulbs, spinal cord, perineurium and/or nerve fibres of spinal nerves in cauda equine (peak score = 2, n = 4/9) Mn in meninges, neuropil of brain and cranial cervical spinal cord (peak score = 1, n = 4/6) Mn in meninges, neuropil of brain near CVO and cranial cervical spinal cord (peak score = 1, n = 2/6)
MVE1-51 (weanling NZWRs) No pathology (n = 0/3) Mn with occasional htl in meninges, neuropil of brain (extensive with neuronophagia), olfactory bulbs, spinal cord, perineurium of spinal nerves and/or dorsal root ganglion in cauda equine (peak score = 3, n = 6/6) Mn,with occasional htl in meninges, neuropil of brain (extensive) with neuronophagia+ (peak score = 3, n = 4/6) Mn,with occasional htl in meninges, neuropil of brain (extensive)+ (peak score = 2, n = 2/6)
WNVNSW2011 (CTRs) No pathology (n = 0/3) Mn in meninges, neuropil of brain and spinal cord (peak score = 2, n = 1/3) N/D N/D
WNVTX8667 (CTRs) No pathology (n = 0/3) Mn in meninges and neuropil of brain (extensive; peak score = 3, n 2/3) N/D N/D

Mn, mononuclear leukocytes; Htl, heterophils; CVO, circumventricular organ; peak score, peak neuropathology score in the CNS (out of 5). + Spinal cord and olfactory bulbs were not examined, N/D: not done.