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. 2015 Aug 28;6(3):777–789. doi: 10.3390/genes6030777

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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The variant allele lacks methylation at CpG position 1 of the IGF2 DMR. Bisulfite sequencing of cloned alleles for four umbilical cord blood DNA specimens (UCB1-UCB4) and two cervical biopsy specimens (CVX1-CVX2) from individuals carrying the variant allele. Each line represents a given clone and each circle represents one of the CpG dinucleotides within the IGF2 DMR. Filled circles indicate that the cytosine was methylated and the unfilled circles indicate that the cytosine was unmethylated within that clone. The data indicate that the variant T allele exhibits a lack of methylation at the first CpG site within the IGF2 DMR.