Mechanisms preventing negative feedback between non-coding transcription and lncRNA-mediated nucleosome positioning. Pol V produces lncRNA, which serves as a binding scaffold for RNA-binding proteins including IDN2 (top). IDN2 recruits the SWI/SNF chromatin remodeling complex, which positions nucleosomes. Positioned nucleosomes contribute to repression of Pol II transcription. In a subsequent round of transcription (bottom) the previously positioned nucleosome could prevent Pol V from transcribing and reinforcing silencing. The RDD complex, which includes the putative chromatin remodeler DRD1, is proposed to remove the nucleosome and facilitate Pol V transcription, thereby preventing negative feedback between lncRNA and lncRNA-mediated nucleosome positioning.