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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Trends Cell Biol. 2015 Oct;25(10):623–632. doi: 10.1016/j.tcb.2015.07.002

Figure 1.

Figure 1

Mechanisms preventing negative feedback between non-coding transcription and lncRNA-mediated nucleosome positioning. Pol V produces lncRNA, which serves as a binding scaffold for RNA-binding proteins including IDN2 (top). IDN2 recruits the SWI/SNF chromatin remodeling complex, which positions nucleosomes. Positioned nucleosomes contribute to repression of Pol II transcription. In a subsequent round of transcription (bottom) the previously positioned nucleosome could prevent Pol V from transcribing and reinforcing silencing. The RDD complex, which includes the putative chromatin remodeler DRD1, is proposed to remove the nucleosome and facilitate Pol V transcription, thereby preventing negative feedback between lncRNA and lncRNA-mediated nucleosome positioning.