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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Trends Cell Biol. 2015 Oct;25(10):623–632. doi: 10.1016/j.tcb.2015.07.002

Figure 3.

Figure 3

Proposed unique features that make lncRNA a versatile factor in controlling chromatin structure.

(a) lncRNA may work in cis by staying attached to the transcribing RNA polymerase. Nascent lncRNA provides a binding site for RNA binding proteins. RNA-binding proteins interact with lncRNA by a sequence- or structure-specific mechanism.

(b) lncRNA may work in trans by combining nucleotide sequence and complex three-dimensional structure. Sequence complementarity may facilitate lncRNA binding to specific loci in the genome. A complex three-dimensional structure may allow interaction with proteins that are recruited to chromatin or mediate chromosome looping.