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. 2015 Sep 15;6:286. doi: 10.3389/fgene.2015.00286

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Copyright © 2015 Overgaard, Frøsig, Welner, Rasmussen, Ilsøe, Sørensen, Andersen, Buus and Jungersen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the adjuvant systems used in the immunization trial. The three Th1-inducing adjuvants CAF09, CASAC, and ISA 51 VG were compared on the basis of their ability to generate responses (A) and the total amount of peptide-specific IFN-γ produced from the culture (B) at the various time points following immunization. For peptides found to be stably binding to MHC class I in the SPA analysis, half-life of the peptide-MHC class I complex was correlated to the amount of IFN-γ (C) and the stimulation index (D).