Table 1.

Plant Mediator subunits involved in growth and development.

Growth and development	Gene name	Functions in brief	Interacting proteins	References
Embryonic development	MED12/GCT	Mediates embryo pattern formation repressing the transcriptional program mediated by KANADI 1 and KANADI 2	Unknown	Gillmor et al., 2010, 2014
	MED13/CCT/Macchi Bou2 (MAB2)	Mediates embryo pattern formation. Additionally, involved in auxin signaling	Unknown	Gillmor et al., 2010, 2014; Ito et al., 2011
Flower development	AtMED25/PFT1	Positively controls Constant (CO) and FT expression, promotes self-destruction by proteasome-mediated degradation	MBR1 and MBR2	Inigo et al., 2012a,b
	AtMED8	Involved in flowering. Transcript of FLC and FT were high and low, respectively in Atmed8	Unknown	Kidd et al., 2009
	AtMED12	Positive regulator of flowering	Unknown	Imura et al., 2012
	AtMED18	Has role in flowering. Binds with the promoter of FLC along with AtSUF4, keeps the expression level of FLC under control	AtSUF4	Zheng et al., 2013; Lai et al., 2014
Root development	AtMED25	The mutant is root hairless. The expression level of class III peroxidases got affected	Unknown	Sundaravelpandian et al., 2013
	AtMED8	Mechanistically similar to MED25, but may be in a different pathway	Unknown	Sundaravelpandian et al., 2013
Other growth and developmental events	AtMED25/PFT1	Mutants form large organs, partly because of increasing expression levels of expansions genes, AtEXP1, AtEXP3, AtEXP5, AtEXP9, AtEXP11, and AtEXPB3	Unknown	Xu and Li, 2011
	AtMED8	Positively controls the organ size	Unknown	Xu and Li, 2012
	AtMED14/SWP	The mutant has reduced leaf number and size, and disorganized SAM	LEUNIG; SMP1 and SMP2 (Probable)	Autran et al., 2002; Clay and Nelson, 2005; Gonzalez et al., 2007
	AtMED18	The mutant has floral deformities. It controls expression of floral homeotic genes like AP1, PI, and AG	Unknown	Kim et al., 2011; Zheng et al., 2013
	AtMED16	Regulates iron homeostasis in plants. Controls marker genes of iron homeostasis like IRT1, FRO2	AtMED25, FIT	Yang et al., 2014; Zhang et al., 2014
	OsMED4	Mutants are embryonic lethal. Speculated to be involved in rice tiller growth	OsSAD1 (RPA 34.5)	Li et al., 2014
	AtCDK8/HEN3	Controls the specification of stamen and carpel. Has an inhibitory role on AG, AP1, and AP2 expression	CTD domain of RNAP II	Wang and Chen, 2004
	AtMED5a and AtMED5b	Involved in active transcriptional processes which inhibit growth and lignin biosynthesis in plants	Unknown	Bonawitz et al., 2012, 2014