Figure 1.

Effect of a continuously present noncognate NT, at varying concentrations c, on the response of a patch of recombinant receptors to a short (10 ms) pulse of a saturating concentration of their NT agonist, as calculated from the kinetic model with parameter values as detailed in Lee et al. (2015). (A) Representative traces, expressed as the fraction of receptors in the conducting state vs. time, for c = 0 mM (solid line), 0.5 mM (dashed line), 1.2 mM (dotted line), 2.4 mM (dash-dotted line), and 4.0 mM (long dash-dotted line). (B) Total ion flux (i.e., the integrated current) relative to ion flux in the absence of noncognate NT, as a function of c.