Figure 1.

Complex pharmacology of antipsychotics and their major metabolites (forming the active moiety of currently used antipsychotic medication) illustrated by the pKa (−10logK_i) against the human receptors, where Ki is the affinity of the drug determined by tracer displacement studies. More peripheral readouts correspond to higher affinities. Data are derived from the standardized PDSP database (http://pdsp.med.unc.edu/indexR.html). It is clear that many antipsychotics have complex pharmacologies leading to non-linear interactions in the human networks. (A) pharmacology of active moiety of aripiprazole, haldoperidol, and olanzapine, (B) pharmacology of risperidone and quetiapine.