Table 3.
Whole-brain structural and functional neuroimaging results in the whole sample (ALL; n = 37) and in the PTSD group.
| Contrast | Region | BA | ALL |
PTSD |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MNI | K | t | p | MNI | K | t | p | |||
| VBM SDS− | R anterior cingulate cortex | 24/32 | 14 24 20 | 1897 | 4.35 | <0.001 | 12 25 17 | 2796 | 5.70 | <0.001 |
| R amygdala | – | 23 −3 −33 | 10140 | 3.39 | 0.001 | 29 0 −26 | 2527 | 3.51 | 0.003 | |
| L amygdala | – | −23 0 −35 | 16363 | 2.76 | 0.003 | – | – | – | – | |
| R hippocampus | – | 27 −7 −31 | 10140 | 2.81 | 0.003 | – | – | – | – | |
| L hippocampus | – | −31 −12 −30 | 16363 | 2.96 | 0.003 | −35 −13 −30 | 18728 | 3.08 | 0.003 | |
| R anterior insula | 13 | 42 17 −26 | 10140 | 3.32 | 0.001 | 41 11 4 | 800 | 4.06 | 0.001 | |
| L anterior insula | 13 | −42 13 −26 | 16363 | 3.56 | 0.001 | −40 12 −23 | 18728 | 3.96 | 0.001 | |
| R posterior insula | 13 | 38 −2 −19 | 10140 | 3.96 | <0.001 | 38 −1 −21 | 2527 | 4.48 | <0.001 | |
| L posterior insula | 13 | −36 −6 −19 | 10140 | 3.63 | 0.001 | −35 −8 −16 | 18728 | 3.66 | 0.001 | |
| R parahippocampal cortex | 28/36 | 20 −7 −41 | 10140 | 3.49 | 0.001 | – | – | – | – | |
| L parahippocampal cortex | 28/36 | −27 −6 −39 | 16363 | 2.94 | 0.003 | – | – | – | – | |
| R dorsolateral prefrontal cortex | 10/46 | 35 50 3 | 806 | 4.19 | <0.001 | – | – | – | – | |
| R orbitofrontal cortex | 11 | – | – | – | – | 20 36 −23 | 1135 | 3.84 | 0.001 | |
| L postcentral gyrus | 1/2/3 | – | – | – | – | −46 −23 33 | 1031 | 4.67 | <0.001 | |
| L striatum | – | −12 11 −18 | 1175 | 3.38 | 0.001 | 0 12 −20 | 1471 | 4.51 | <0.001 | |
| SPECT SDS+ | L/R dorsal midbrain | – | 2 −24 −18 | 459 | 4.39 | <0.001 | 4 −28 −22 | 319 | 4.81 | <0.001 |
| R precuneus | 7 | 12 −52 32 | 302 | 3.37 | 0.001 | 10 −54 30 | 590 | 3.35 | 0.003 | |
| L precuneus | 7 | −12 −54 26 | 302 | 3.59 | 0.001 | −12 −52 28 | 590 | 5.00 | <0.001 | |
| R posterior insula | 13 | 34 −22 0 | 562 | 4.30 | <0.001 | – | – | – | – | |
| L posterior insula | 13 | – | – | – | – | −42 −30 6 | 316 | 3.52 | 0.002 | |
| SPECT SDS− | L/R anterior cingulate cortex | 24/32 | 2 42 14 | 700 | 3.71 | <0.001 | 042 16 | 2651 | 4.90 | <0.001 |
| R dorsolateral prefrontal cortex | 9 | – | – | – | – | 24 46 24 | 2651 | 4.69 | <0.001 | |
| L orbitofrontal cortex | 11 | – | – | – | – | −16 48 −18 | 2651 | 5.83 | <0.001 | |
SDS+/−, positive/negative correlations with the sleep disturbances score; L/R, left/right; BA, Brodmann area; MNI, Montreal Neurological Institute coordinates (x, y, z); K, cluster size; t, Student’s t-statistic; p, statistical significance at peaks (uncorrected at cluster-level).