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Highlighted BR structure with the retinal chromophore, W86, W182, and Y185 (PDB: 1QM8). Y83, W86, and W182 are strongly conserved among the microbial rhodopsins (orange). Aromatic residues are strongly conserved at the Y185, W189, and F219 positions (yellow). In BR, W86, W182, Y185, and W189 constitute the chromophore binding pocket for all-trans retinal (red).
