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. 2015 Sep 23;8:52. doi: 10.3389/fnmol.2015.00052

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Copyright © 2015 Jia, Liu, Sun, Chang, Yang, Ji, Yang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagrammatic presentation of the experimental protocol (A,B) and the position of intracerebroventricular (i.c.v.) cannulation confirmed by the hematoxylin-eosin (HE) staining in the 16-month old mice (C).