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. 2015 Sep 23;8:52. doi: 10.3389/fnmol.2015.00052

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Copyright © 2015 Jia, Liu, Sun, Chang, Yang, Ji, Yang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of the cognition and histone acetylation in the 3- and 16-month old mice after surgery. (A,B) Performance of total distance traveled and time spent in the center during the open field test. Data are presented as the mean ± S.E.M. (n = 16). (C) Performance of freezing time during the fear conditioning training session. Data are presented as the mean ± S.E.M. (n = 16). (D,E) Performance during fear conditioning tests 2- or 24-h after laparotomy. Data are presented as the mean ± S.E.M. (n = 8). (F) The acetylation level of histone H3 and H4 in the 3- or 16-month-old mice after laparotomy. Results are mean ± S.E.M. (n = 3). *p < 0.05 compared with the 16-month old mice subjected to sham surgery.