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. 2015 Sep 23;8:52. doi: 10.3389/fnmol.2015.00052

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Copyright © 2015 Jia, Liu, Sun, Chang, Yang, Ji, Yang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of suberoylanilide hydroxamic acid (SAHA) treatment on the cognitive performance in the 16-month old mice after surgery. (A,B) Performance of total distance traveled and time spent in the center during the open field test. Data are presented as the mean ± S.E.M. (n = 16). (C) Performance of freezing time during the fear conditioning training session. Data are presented as the mean ± S.E.M. (n = 16). (D,E) Performance during the fear conditioning tests 2- or 24-h after laparotomy. Data are presented as the mean ± S.E.M. (n = 8). *p < 0.05 compared with the Sham + Vehicle group; ^#p < 0.05 compared with the Laparotomy + Vehicle group.