Table 1.

Infectivity of purified intestinal samples from the in vivo study in naïve C57BL/6 IFNγR-KO mice.

		Day 10b		Day 17b		Day 35b
Treatmenta		Microscopy	qPCR	Microscopy	qPCR	Microscopy	qPCR
PBS	Day 10	Yes	Yes	-	-	-	-
	Day 30	-	-	-	-	-	-
100 mg/kg of paromomycin	Day 10	Yes	Yes	-	-	-	-
	Day 30	-	-	-	-	-	-
10 mg/kg of miltefosine	Day 10	Yes	Yes	-	-	-	-
	Day 30	No	No	Yes	Yes	-	-
20 mg/kg of OlPC	Day 10	Yes	Yes	-	-	-	-
	Day 30	No	No	Yes	Yes	-	-
30 mg/kg of OlPC	Day 10	Yes	Yes	-	-	-	-
	Day 30	No	No	Yes	Yes	-	-
40 mg/kg of OlPC	Day 10	No	No	No	Yes	-	-
	Day 30	No	No	No	No	No	No

^aTreatment given to mice during the in vivo study. Purified intestinal samples from these mice at Days 10 or 30 were used to infect naïve C57BL/6 IFNγR-KO mice.

^bRepresents the day post-inoculation that the stool from naïve mice was collected. The presence of C. parvum oocysts or its DNA in the stool of naïve mice is scored qualitatively. Dashes represent no available data due to mouse mortality during study: either there was no purified intestinal sample available to inoculate naïve mice (i.e., no PBS-treated mice in the in vivo study survived until Day 30) or naïve mice died during rechallenge study (no naïve mice inoculated with purified intestinal samples from mice treated with miltefosine survived until stool collection on Day 35).