Figure 10.

Restitution properties with the (Walker et al., 2014)-RyR model. (A) Membrane potential. (B) Average cytosolic [Ca²⁺]_i]. (C) Average cytosolic ${[C{a}^{2+}]}_i^{exp}$ as defined in Equation (20). Solid line: basic cycle length (BCL) = 350 ms; dashed line: BCL = 300 ms; dotted line: BCL = 250 ms. At cycle length 350 ms the DI was 177 ms. At cycle length 300 ms the DI was 132 ms. At cycle length 225 ms the DI was 87 ms. (D) Constant BCL Restitution Curve (Otani and Gilmour, 1997). For clarity, the AP with the shortest DI in (D) is not shown in (A–C). These simulations have been carried out with a single z-disc.