Figure 3.

Simulation results of the inflammatory cascade following transplant surgery and non-allo-Ag graft placement (i.e., α = 0). Combined initial host and graft IRI can synergize to incite an inflammatory response that (A–D) cannot resolve, causing graft failure or (E–H) transiently decrease graft function significantly. (A–C) present a series of simulations in which (A) a moderate level of initial surgical IRI in the host is considered with no corresponding graft IRI associated with the placement, (B) no initial surgical IRI in the host is considered with a low level of initial graft IRI, or (C) the moderate level of initial surgical IRI in the host of simulation (A) is coupled with the low level of initial graft IRI of simulation (B). In (D), the graft functionality curves corresponding to simulations (A–C) are shown. The “Graft function for C” time course in (D) displays the synergy to severely affect graft function such that the graft fails, shown as functionality decreasing to and remaining at 12%. Similarly, panels (E–G) display outcomes for (E) a low/moderate level of initial surgical IRI in the host with no corresponding graft IRI associated with the placement, (F) no initial surgical IRI in the host with a corresponding moderate level of initial graft IRI, or (G) the combination of the low/moderate initial level of surgical IRI in the host from simulation (E) with the moderate level of initial graft IRI from simulation (F). In (H), the graft functionality curves corresponding with (E–G) are shown. The “Graft function for G” time course in (H) displays the synergy to significantly affect graft function, but only transiently after which the graft functionality fully recovers. Initial conditions for (C): (I₀, D₀, A₀, D_G0, T_P0, T_A0) = (0, 3, 0.5, 0.125, 0, 0); initial conditions for (G): (I₀, D₀, A₀, D_G0, T_P0, T_A0) = (0, 2, 1, 0.125, 0, 0).