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. 2015 Sep 22;6:140. doi: 10.3389/fendo.2015.00140

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Copyright © 2015 Grzesik, Kreuchwig, Rutz, Furkert, Wiesner, Schuelein, Kleinau, Gromoll and Krause.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extension of the hinge region in the homology model of the ectodomain of LHCGR with hLH bound to both the leucine-rich-repeat domain (LRRD) (wheat) and to this extension of the hinge region (lilac). The two predicted helices within the middle of hinge region, the exon10-helix (orange) and the adjacent helix (gray), interact with the alpha-subunit of hLH. The following sulfation group of sTyr331 (yellow) binds in a binding pocket between the alpha-subunit (blue) and beta-subunit (green) of hLH. The specific conformation of the hLH beta-subunit in the L2-beta loop caused by ⁷⁰PPLP (colored in red) that differs from hCG (see also fig 2 colored in green) performs more productive H-bond interactions (insert upper right panel) than hCG.