Table 3.

List of bioactive compounds produced by thermophilic and alkaliphilic actinobacteria.

Actinomyces isolates	Bioactive compounds	Activity	References
THERMOPHILIC ACTINOBACTERIA
Excellospora viridilutea SF2315 [reclassified as Actinomadura viridilutea (Zhang et al., 2001)]	SF2315A and B	Antibacterial	Sasaki et al., 1988
Streptomyces thermophilus	Thermomycin	Antibacterial	Schone, 1951
Thermomonospora sp.	T-SA-125	Antibacterial	Dewendar et al., 1979
Streptomyces refuineus subsp. thermotolerans	Anthramycin	Antitumor Antimicrobial	Hu et al., 2007
Microbispora aerata	Diketopiperazine	Neuroprotective agents	Ivanova et al., 2013
Microbispora aerata	Microbiaeratin	Antiproliferative and cytotoxic drug	Ivanova et al., 2007
Marinactinospora thermotolerans	β-Carboline and indolactam alkaloids	Antimalarial	Huang et al., 2011
ALKALIPHILIC ACTINOBACTERIA
Streptomyces werraensis	Erythromycin	Antibacterial	Sanghvi et al., 2014
Nocardiopsis dassonvillei WA52	WA52-A Macrolide	Antifungal	Ali et al., 2009
Streptomyces sp. No. 1543	Antimycin A	Antifungal	Sato et al., 1985
Streptomyces sp. DPTTB16	4′Phenul-1-napthyl-phenyl acetamide	Antifungal	Dhanasekaran and Panneerselvam, 2008
Streptomyces griseus Var. autotrophicus	Faeriefungin	Antimicrobial and insecticidal activity	Nair et al., 1989
Streptomyces strain	Pyrocoll	Antiparasitic Antitumor	Dietera et al., 2003
Nocardiopsis sp.	Griseusin D	Anticancer	Li et al., 2007a
Nocardiopsis alkaliphila YIM-80379	Nocardiopyrones A and B	Antimicrobial	Wang et al., 2013
Nocardiopsis terrae YIM 90022	Quinolone alkaloid and N-acetyl-anthranilic acid	Antimicrobial	Tian et al., 2014