Table 4.

Pharmaceutically valuable compounds and enzymes produced by thermophilic and alkaliphilic actinobacteria.

Biological compounds	Actinobacteria isolates	Uses	References
ANTIOXIDANTS AND ANTI-INFLAMMATORY COMPOUNDS
Melanin	Streptomyces lusitanus DMZ-3	Cytotoxic compound	Madhusudhan et al., 2014
	Streptomyces sp.	Antioxidant	Quadri and Agsar, 2012
	Streptomyces species D5	Neurogenic disorder treatment	Diraviyam et al., 2011
Ferulic acid	Thermobifida fusca PU13-13	Antioxidant	Huang et al., 2013
		Anti-inflammatory
Canthaxanthin	Dietzia sp. K44	Antioxidant	Venugopalan et al., 2013
		Feed additive
		Cosmetics
Carotenoids	Dietzia natronolimnaea HS-1	Antioxidant	Gharibzahedi et al., 2014
		Feed additive
		Cosmetics
PHARMACEUTICALLY VALUABLE ENZYMES
Vitamin D3 hydroxylase	Pseudonocardia autotrophica	Bone metabolism	Fujii et al., 2009
		Immunity
		Cell growth regulators
Fibrinolytic enzyme	Streptomyces sp. MCMB-379	Blood clot dissolution	Chitte et al., 2011
	Streptomyces megasporus SD5		Chitte and Dey, 2002
Recombinant Asparaginase	Streptomyces thermoluteus subsp. fuscus NBRC 14270	Leukaemia treatment	Hatanaka et al., 2011a
L-Glutaminase	Alkaliphilic Streptomyces sp. SBU1	Leukaemia treatment	Krishnakumar et al., 2011
Ribonuclease	Alkaliphilic Streptomyces sp. M49-1	Antiviral	Demir et al., 2013
PrPSc-degrading enzyme keratinase	Nocardiopsis strain TOA-1	Antiprion drug	Mitsuiki et al., 2010
Recombinant X-prolyl-dipeptidyl aminopeptidases (XDAP)	Streptomyces thermoluteus subsp. fuscus NBRC 14270	Antidiabetic agents	Hatanaka et al., 2011b
	S. thermocyaneoviolaceus NBRC 14271
ALDOSE REDUCTASE INHIBITOR
YUA001	Corynebacterium sp. YUA25	Antidiabetic agents	Bahn et al., 1998
DNA POLYMERASE INHIBITORS
Topostatin	Thermomonospora alba Strain No. 1520 III [reclassified as Thermobifida alba (Zhang et al., 1998)]	Antiviral	Suzuki et al., 1998
Isoaurostatin	Thermomonospora alba [reclassified as Thermobifida alba (Zhang et al., 1998)]	Antiviral	Suzuki et al., 2001