Table 2. Baseline characteristics of male and female subcohort members in the Netherlands Cohort Study (1986–2002), according to tertiles of the genetic sum score of unfavorable alleles in genes related to the IGF pathway.
| Baselinecharacteristics | Male subcohort |
Female subcohort |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic sum scorea,b |
Genetic sum scorea,b |
|||||||||||
| Tertile 1 |
Tertile 2 |
Tertile 3 |
Tertile 1 |
Tertile 2 |
Tertile 3 |
|||||||
| N (%) | Mean(SD) | N (%) | Mean(SD) | N (%) | Mean(SD) | N (%) | Mean(SD) | N (%) | Mean(SD) | N (%) | Mean(SD) | |
| Age, years | 61.3 (4.1) | 61.3 (4.3) | 61.5 (4.1) | 61.4 (4.2) | 61.5 (4.3) | 61.2 (4.3) | ||||||
| Family history of CRC (yes) | 28 (4.8) | 37 (6.1) | 22 (6.0) | 27 (4.8) | 40 (7.3) | 23 (5.8) | ||||||
| Diabetes after age 30 (yes) | 37 (3.7) | 21 (3.5) | 8 (2.2) | 15 (2.7) | 21 (3.8) | 11 (2.8) | ||||||
| Adult BMI, kg/m2 | 24.9 (2.6) | 24.9 (2.7) | 25.0 (2.5) | 25.4 (3.9) | 25.1 (3.5) | 25.0 (3.2) | ||||||
| Adult trouser/skirt size (≥median) | 318 (59.3) | 351 (63.9) | 208 (62.5) | 316 (56.9) | 308 (56.7) | 230 (59.4) | ||||||
| Height, cm | 176.2 (6.5) | 176.7 (6.4) | 176.8 (7.2) | 164.7 (6.4) | 165.5 (6.1) | 165.1 (5.8) | ||||||
| BMI at age 20, kg/m2 | 21.7 (2.3) | 21.5 (2.4) | 21.9 (2.5) | 21.4 (2.7) | 21.4 (2.8) | 21.5 (2.9) | ||||||
| Occupational physical activityc | ||||||||||||
| <8 kJ/min | 319 (60.7) | 309 (58.4) | 194 (59.3) | |||||||||
| 8-12 | 134 (25.5) | 144 (27.2) | 97 (29.7) | |||||||||
| >12 | 73 (13.9) | 76 (14.4) | 36 (11.0) | |||||||||
| Non-occupational physical activity | ||||||||||||
| ≤30 min/day | 108 (18.5) | 102 (17.2) | 62 (17.0) | 135 (24.4) | 139 (25.5) | 85 (21.6) | ||||||
| >30-60 | 167 (28.6) | 205 (34.5) | 122 (33.4) | 174 (31.5) | 162 (29.7) | 147 (37.3) | ||||||
| >60-90 | 110 (18.8) | 107 (18.0) | 67 (18.4) | 128 (23.2) | 118 (21.6) | 91 (23.1) | ||||||
| >90 | 199 (34.1) | 180 (30.3) | 114 (31.2) | 116 (21.0) | 127 (23.3) | 71 (18.0) | ||||||
| Smoking status | ||||||||||||
| Never | 84 (14.3) | 75 (12.4) | 42 (11.4) | 326 (57.9) | 322 (58.3) | 234 (59.4) | ||||||
| Ex | 311 (52.9) | 318 (52.7) | 204 (55.3) | 125 (22.2) | 110 (19.9) | 83 (21.1) | ||||||
| Current | 193 (32.8) | 210 (34.8) | 123 (33.3) | 112 (19.9) | 120 (21.7) | 77 (19.5) | ||||||
| Alcohol intake | ||||||||||||
| 0 g/day | 75 (12.9) | 82 (13.9) | 58 (15.7) | 193 (35.9) | 170 (31.9) | 101 (27.0) | ||||||
| 0.1-29 | 412 (70.8) | 422 (71.3) | 262 (71.0) | 330 (61.5) | 350 (65.7) | 252 (67.4) | ||||||
| ≥30 | 95 (16.3) | 88 (14.9) | 49 (13.3) | 14 (2.6) | 13 (2.4) | 21 (5.6) | ||||||
| Meat intake, g/day | 105.9 (44.1) | 106.2 (43.5) | 102.0 (39.8) | 91.9 (41.7) | 90.5 (38.4) | 98.1 (37.8) | ||||||
| Processed meat intake, g/day | 16.8 (16.9) | 17.3 (18.3) | 16.1 (16.5) | 10.3 (12.5) | 11.3 (11.9) | 11.3 (12.6) | ||||||
| Total energy intake, kcal/day | 2,161 (493) | 2,167 (507) | 2,136 (464) | 1,660 (399) | 1,670 (370) | 1,720 (389) | ||||||
Abbreviations: BMI, body mass index; CRC, colorectal cancer; IGF, insulin-like growth factor; N, number of; SD, standard deviation
aThe range in tertiles of the literature-based genetic sum score was 6–14, 15–18, and 19–29 unfavorable alleles. The theoretical maximum was 36.
bChi-square and ANOVA tests showed no differences in most baseline characteristics between tertiles of the genetic sum score in men and women (P > 0.05), except for alcohol, meat, and total energy intake in women (P = 0.005, 0.01, and 0.048, respectively).
cWomen in the Netherlands Cohort Study were mostly homemakers; few held jobs or only for a brief number of years in the distant past.