Table 4. Age-adjusted Hazard Ratios (HR) and 95% Confidence Intervals (CI) for Colorectal Cancer in Relation to SNPs in Genes in the Insulin-like Growth Factor Pathway in Men and Women in the Netherlands Cohort Study (1986–2002).
| Colorectal cancer |
||||||||
|---|---|---|---|---|---|---|---|---|
| Men |
Women |
|||||||
| PY | N cases | HR | (95% CI) | PY | N cases | HR | (95% CI) | |
| IGF1 | ||||||||
| rs1520220 | ||||||||
| CC | 15,286 | 895 | 1 | reference | 15,700 | 603 | 1 | reference |
| CG | 6,178 | 414 | 1.15 | (0.97, 1.35) | 7,207 | 277 | 1.00 | (0.83, 1.19) |
| GG | 704 | 54 | 1.37 | (0.92, 2.05) | 765 | 31 | 1.03 | (0.65, 1.63) |
| P-trend | 0.04 | 0.98 | ||||||
| rs5742678 | ||||||||
| CC | 12,877 | 745 | 1 | reference | 13,025 | 497 | 1 | reference |
| GC | 7,912 | 519 | 1.14 | (0.98, 1.34) | 9,086 | 355 | 1.01 | (0.85, 1.20) |
| GG | 1,379 | 98 | 1.25 | (0.92, 1.69) | 1,561 | 59 | 0.98 | (0.69, 1.37) |
| P-trend | 0.05 | 0.97 | ||||||
| rs5742694 | ||||||||
| TT | 13,469 | 778 | 1 | reference | 13,695 | 518 | 1 | reference |
| GT | 7,462 | 487 | 1.13 | (0.97, 1.33) | 8,568 | 341 | 1.03 | (0.86, 1.22) |
| GG | 1,237 | 96 | 1.38 | (1.01, 1.88) | 1,410 | 51 | 0.96 | (0.67, 1.37) |
| P-trend | 0.02 | 0.95 | ||||||
| rs10735380 | ||||||||
| AA | 12,365 | 724 | 1 | reference | 12,983 | 469 | 1 | reference |
| AG | 8,346 | 533 | 1.10 | (0.94, 1.28) | 9,052 | 378 | 1.14 | (0.96, 1.35) |
| GG | 1,456 | 105 | 1.25 | (0.93, 1.67) | 1,638 | 64 | 1.06 | (0.76, 1.47) |
| P-trend | 0.09 | 0.26 | ||||||
| IGFBP3 | ||||||||
| rs2854744 | ||||||||
| AA | 4,654 | 279 | 1 | reference | 4,778 | 193 | 1 | reference |
| CA | 11,173 | 690 | 1.04 | (0.85, 1.26) | 11,750 | 446 | 0.93 | (0.75, 1.15) |
| CC | 6,341 | 393 | 1.03 | (0.83, 1.28) | 7,128 | 270 | 0.96 | (0.76, 1.22) |
| P-trend | 0.80 | 0.82 | ||||||
| rs2132572 | ||||||||
| GG | 13,360 | 768 | 1 | reference | 13,901 | 518 | 1 | reference |
| GA | 7,661 | 510 | 1.12 | (0.96, 1.31) | 8,476 | 343 | 1.07 | (0.90, 1.27) |
| AA | 1,147 | 85 | 1.29 | (0.93, 1.79) | 1,295 | 50 | 1.06 | (0.73, 1.54) |
| P-trend | 0.06 | 0.49 | ||||||
| rs35440925 | ||||||||
| CC | 13,704 | 882 | 1 | reference | 14,615 | 579 | 1 | reference |
| CG | 7,479 | 422 | 0.89 | (0.76, 1.05) | 8,113 | 294 | 0.92 | (0.77, 1.10) |
| GG | 985 | 59 | 0.97 | (0.67, 1.39) | 944 | 37 | 1.02 | (0.67, 1.57) |
| P-trend | 0.27 | 0.54 | ||||||
| IRS1 | ||||||||
| rs1801278 | ||||||||
| GG | 19,004 | 1,155 | 1 | reference | 20,576 | 789 | 1 | reference |
| GA | 3,017 | 203 | 1.11 | (0.90, 1.37) | 3,047 | 119 | 1.03 | (0.80, 1.31) |
| AA | 147 | 5 | 0.60 | (0.20, 1.77) | 49 | 3 | 2.33 | (0.47, 11.65) |
| P-trend | 0.58 | 0.66 | ||||||
| IRS2 | ||||||||
| rs1805097 | ||||||||
| AA | 2,709 | 151 | 1 | reference | 3,018 | 111 | 1 | reference |
| GA | 10,044 | 604 | 1.07 | (0.84, 1.36) | 10,621 | 405 | 1.01 | (0.77, 1.32) |
| GG | 9,274 | 603 | 1.15 | (0.90, 1.47) | 9,985 | 392 | 1.07 | (0.82, 1.40) |
| P-trend | 0.20 | 0.51 | ||||||
| rs2289046 | ||||||||
| GG | 2,511 | 134 | 1 | reference | 2,838 | 109 | 1 | reference |
| GA | 10,059 | 607 | 1.13 | (0.88, 1.46) | 10,676 | 398 | 0.94 | (0.72, 1.23) |
| AA | 9,598 | 622 | 1.20 | (0.93, 1.55) | 10,158 | 404 | 1.03 | (0.78, 1.34) |
| P-trend | 0.15 | 0.57 | ||||||
| rs754204 | ||||||||
| CC | 5,876 | 336 | 1 | reference | 6,496 | 248 | 1 | reference |
| TC | 11,128 | 694 | 1.08 | (0.91, 1.30) | 11,468 | 438 | 0.98 | (0.81, 1.20) |
| TT | 4,754 | 326 | 1.17 | (0.95, 1.45) | 5,291 | 215 | 1.04 | (0.82, 1.31) |
| P-trend | 0.14 | 0.78 | ||||||
| rs4773082 | ||||||||
| TT | 6,560 | 357 | 1 | reference | 6,954 | 249 | 1 | reference |
| CT | 10,190 | 623 | 1.11 | (0.93, 1.33) | 10,299 | 382 | 1.00 | (0.82, 1.23) |
| CC | 3,813 | 243 | 1.12 | (0.89, 1.41) | 4,082 | 152 | 1.03 | (0.80, 1.33) |
| P-trend | 0.27 | 0.81 | ||||||
| GHRHR | ||||||||
| rs4988496 | ||||||||
| GG | 19,743 | 1,204 | 1 | reference | 20,791 | 813 | 1 | reference |
| AG | 2,346 | 153 | 1.05 | (0.83, 1.33) | 2,783 | 93 | 0.86 | (0.66, 1.12) |
| AA | 63 | 4 | 1.02 | (0.25, 4.10) | 98 | 5 | 1.32 | (0.40, 4.38) |
| P-trend | 0.72 | 0.39 | ||||||
| PPARG | ||||||||
| rs1801282 | ||||||||
| GG | 187 | 12 | 1 | reference | 389 | 12 | 1 | reference |
| GC | 4,814 | 280 | 0.86 | (0.38, 1.95) | 4,916 | 194 | 1.26 | (0.61, 2.58) |
| CC | 17,151 | 1,071 | 0.92 | (0.41, 2.06) | 18,363 | 705 | 1.21 | (0.60, 2.44) |
| P-trend | 0.58 | 0.93 | ||||||
| ADIPOQ | ||||||||
| rs1501299 | ||||||||
| AA | 1,620 | 103 | 1 | reference | 1,710 | 51 | 1 | reference |
| CA | 8,834 | 108 | 0.92 | (0.68, 1.23) | 8,779 | 366 | 1.39 | (0.97, 1.98) |
| CC | 11,715 | 751 | 1.03 | (0.77, 1.37) | 13,184 | 493 | 1.26 | (0.89, 1.79) |
| P-trend | 0.34 | 0.88 | ||||||
| rs2241766 | ||||||||
| TT | 17,305 | 1,103 | 1 | reference | 18,368 | 729 | 1 | reference |
| GT | 4,562 | 244 | 0.83 | (0.69, 1.00) | 4,849 | 164 | 0.85 | (0.68, 1.05) |
| GG | 170 | 10 | 0.91 | (0.38, 2.16) | 358 | 16 | 1.10 | (0.57, 2.12) |
| P-trend | 0.06 | 0.25 | ||||||
| rs266729 | ||||||||
| GG | 1,329 | 93 | 1 | reference | 1,909 | 60 | 1 | reference |
| GC | 8,742 | 545 | 0.90 | (0.66, 1.23) | 8,479 | 334 | 1.32 | (0.94, 1.86) |
| CC | 12,098 | 724 | 0.84 | (0.62, 1.15) | 13,285 | 517 | 1.29 | (0.93, 1.80) |
| P-trend | 0.22 | 0.36 | ||||||
| rs1648707 | ||||||||
| AA | 9,974 | 597 | 1 | reference | 10,948 | 426 | 1 | reference |
| CA | 10,041 | 616 | 1.03 | (0.88, 1.21) | 9,970 | 393 | 1.00 | (0.84, 1.19) |
| CC | 2,153 | 150 | 1.19 | (0.92, 1.53) | 2,754 | 92 | 0.81 | (0.62, 1.08) |
| P-trend | 0.25 | 0.27 | ||||||
| rs182052 | ||||||||
| GG | 9,900 | 592 | 1 | reference | 10,891 | 424 | 1 | reference |
| GA | 10,085 | 617 | 1.03 | (0.88, 1.21) | 9,966 | 393 | 1.00 | (0.84, 1.19) |
| AA | 2,183 | 154 | 1.20 | (0.93, 1.54) | 2,816 | 94 | 0.82 | (0.62, 1.08) |
| P-trend | 0.23 | 0.29 | ||||||
| ADIPOR1 | ||||||||
| rs1342387 | ||||||||
| AA | 4,266 | 234 | 1 | reference | 4,555 | 195 | 1 | reference |
| GA | 11,418 | 725 | 1.16 | (0.95, 1.42) | 12,350 | 447 | 0.86 | (0.69, 1.06) |
| GG | 6,484 | 403 | 1.12 | (0.90, 1.40) | 6,751 | 267 | 0.94 | (0.74, 1.20) |
| P-trend | 0.42 | 0.77 | ||||||
| rs7539542 | ||||||||
| CC | 10,697 | 671 | 1 | reference | 11,152 | 469 | 1 | reference |
| CG | 9,496 | 566 | 0.95 | (0.82, 1.11) | 10,282 | 361 | 0.84 | (0.71, 1.00) |
| GG | 1,957 | 125 | 0.99 | (0.76, 1.30) | 2,130 | 81 | 0.95 | (0.70, 1.29) |
| P-trend | 0.72 | 0.19 | ||||||
| rs12733285 | ||||||||
| CC | 1,884 | 94 | 1 | reference | 1,610 | 80 | 1 | reference |
| CT | 9,301 | 573 | 1.27 | (0.95, 1.70) | 9,981 | 370 | 0.76 | (0.56, 1.05) |
| TT | 10,971 | 696 | 1.29 | (0.97, 1.72) | 12,008 | 459 | 0.80 | (0.58, 1.09) |
| P-trend | 0.19 | 0.51 | ||||||
| ADIPOR2 | ||||||||
| rs1044471 | ||||||||
| CC | 6,286 | 409 | 1 | reference | 6,861 | 240 | 1 | reference |
| CT | 11,233 | 660 | 0.90 | (0.76, 1.07) | 11,637 | 473 | 1.12 | (0.92, 1.36) |
| TT | 4,614 | 293 | 0.98 | (0.79, 1.21) | 5,141 | 197 | 1.08 | (0.85, 1.37) |
| P-trend | 0.74 | 0.47 | ||||||
| rs767870 | ||||||||
| TT | 14,593 | 923 | 1 | reference | 16,325 | 609 | 1 | reference |
| TC | 6,917 | 403 | 0.91 | (0.77, 1.07) | 6,664 | 278 | 1.13 | (0.94, 1.35) |
| CC | 659 | 37 | 0.87 | (0.56, 1.36) | 668 | 23 | 0.93 | (0.56, 1.57) |
| P-trend | 0.22 | 0.36 | ||||||
Abbreviations: ADIPOQ, adiponectin; ADIPOR1 and -2, adiponectin receptor 1 and 2; CI, confidence interval; GHRHR, growth hormone releasing hormone receptor; HR, hazard ratio; IGF1, insulin-like growth factor 1; IGFBP3, insulin-like growth factor binding protein 3; IRS1 and -2, insulin receptor substrate 1 and 2; N, number of; PPARG, peroxisome proliferator-activated receptor gamma; PY, person-years at risk.