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. 2015 Jun 2;29(5):362–369. doi: 10.7555/JBR.29.20150008

Fig. 2. ET-1 induced mini-stroke in the dorsal hippocampal (DH) region impairs recall of contextual fear memory.

Fig. 2

A: Schematic of fear conditioning protocol. B: Rats with ET-1-induced dorsal hippocampal mini-stroke exhibit normal freezing percentage in a 6-trial training protocol. ITI: inter train interval. C: Freezing during 3 minutes of testing in the training context (*P<0.05, two-tailed Student's t-test) but not in a novel context (P=0.470, two-tailed Student's t-test) is significantly impaired in ET-1 infused rats (sham, n=9, DH-stroke, n=9). D: Tone conditioning is unaffected in ET-1 injected rats 2 hours after training (no significant main effect of treatment, F(1, 42)=1.991, P=0.878).