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. 2015 Jun 28;29(5):405–413. doi: 10.7555/JBR.29.20130092

Table 2. OA score of tissue sections for quantitative histological analyses: OARSI system.

No. Grade Stage Score Characteristics
Group 1 0 0 0 Normal architecture, smooth surface, cells intact with appropriate orientation
Group 2 2.0-2.5 2 4.0-5.0 Wavy and irregular surface, thinning of tibial plateau, diminished hemopoietic tissue with loss of bony spicule
Group 3 3.0-3.5 3 9.0-10.5 Fissures and matrix fibrillation extending deep into the mid zone, large number of necrotic chondrocytes
Group 4 4.0-4.5 3 12.0-13.5 Extensive erosion resulting in excavitation, subchondralhemopoietic tissue replaced by fibrous tissue,
Group 5 5.0-5.5 4 20.0-22.0 Denudation, complete loss of the cartilage and large cysts within the subchondral region
Group 6 2.0 2 4.0 Surface wavy and discontinued, regeneration of the cartilage as cell nest, cortical bone formation with microvasculature
Group 7 1.5 2 3.0 Fibrillation superficially, organized cartilage cells
Group 8 1.5 2 3.0 Few necrotic chondrocytes, few superficial fibrillation
Group 9 1.0 1 1.0 Superficial zone intact, regeneration with cell nest