Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Physical functioning
RCT	66 people with CFS (Oxford criteria) In review	Mean change in short-form (SF)-36 physical function score 12 weeks 20.5 with graded exercise therapy 8.0 with control intervention (flexibility and relaxation training)	P = 0.01	Effect size not calculated	graded exercise therapy
RCT	22 adolescents wit CFS (Fuduka critera) In review	Physical function (SF-36 physical function score) change from baseline to 4 weeks 5.7 with graded exercise therapy 6.4 with control intervention (progressive resistance training)	P = 0.83		Not significant
RCT 4-armed trial	641 adults with CFS (Oxford criteria)	Physical function (SF-36 physical) 52 weeks 57.7 with graded exercise therapy 50.8 with specialist medical care	Mean difference 9.4 95% CI 4.4 to 14.4 P = 0.0005	Effect size not calculated	graded exercise therapy